MANUAL ARTICLE REVIEW IS REQUIRED FOR THIS ARTICLE

Manual article review is required for this article

The extent of absorption of cocaine to the systemic circulation soon after nasal insufflation is comparable to that soon after oral ingestion. The rate of absorption right after nasal insufflation is limited by cocaine-induced vasoconstriction of capillaries from the nasal mucosa. Onset of absorption right after oral ingestion is delayed due to the

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